Impact of phenotyping CYP2D6 in psychiatry

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Authors

ŽOURKOVÁ Alexandra HADAŠOVÁ Eva PILAŘOVÁ Lucie ROBEŠ Miroslav RAVČUKOVÁ Barbora KAŠPÁREK Tomáš

Year of publication 2004
Type Article in Periodical
Magazine / Source Psychiatrie
MU Faculty or unit

Faculty of Medicine

Citation
Field Psychiatry, sexuology
Keywords phenotype; genotype; CYP2D6; clinical outcome
Description The paper deal with comparison of distribution therapeutic efficacy and side effects of long term paroxetine treatment within 50 patients genotyped and phenotyped to determine their metabolic status. No variation in therapeutic efficacy and common adverse effects between subjects classified as poor metabilisers and extensice metabolisers were found. A significantkly higher rate of sexual dysfunction was recored among patients with a PM Phenotype.
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