Antidepressant-like effects of tiagabine on locomotor/exploratory behaviour and leukocyte phagocytosis in rats

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Authors

PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2004
Type Article in Periodical
Magazine / Source European Neuropsychopharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords animal model; depression; olfactory bulbectomy; tiagabine
Description The purpose of the study was to test a potential antidepressant effect of the 3rd generation antiepileptic tiagabine in rats with bilateral olfactory bulbectomy (OB), which is a well-established animal model of human depression resembling behavioural, immune and endocrine changes. In rats we examined tiagabine effect on locomotor/exploratory activities in the open-field test, and on phagocytosis of leukocytes. Compared to the sham-operated animals OB rats showed a characteristic locomotor hyperactivity in the open-field and a significant suppression of leukocyte phagocytosis. Repeated tiagabine treatment (12 mg/kg/day, 10 days, intraperitoneally) elicited a significant decrease of the locomotor hyperactivity in the open field test, and significant disinhibition of leukocyte phagocytosis. Taking into account that clinically approved antidepressants reverse OB related behavioural and immune disorders (Leonard and Tuite, 1981) the results of both present experiments indicate the hypothesized antidepressant activity of tiagabine.
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