Structures of the lectins from Pseudomonas aeruginosa: Insights into molecular basis for host glycan recognition

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Authors

IMBERTY Anne WIMMEROVÁ Michaela MITCHELL Edward P. GILBOA-GARBER Nechama

Year of publication 2004
Type Article in Periodical
Magazine / Source Microbes and Infection
MU Faculty or unit

Faculty of Science

Citation
Field Biochemistry
Keywords lectin; Pseudomonas aeruginosa; cystic fibrosis; crystal structure
Description The opportunistic human pathogen Pseudomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL and PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins are related to their putative roles in host recognition, cell surface adhesion and biofilm formation.
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