FNR rodina regulačních proteinů. Přehled mechanismu aktivace proteinů FNR-typu a jejich funkce při genové expresi anaerobních genů
| Title in English | FNR family of regulatory proteins. Survey of activation mechanism of FNR-like proteins and their function in expression of anaerobic genes |
|---|---|
| Authors | |
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | 22. Kongres Československej spoločnosti mikrobiologickej s medzinárodnou účasťou. ZDRAVIE A MIKROORGANIZMY |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | FNR protein; Escherichia coli; regulation; gene expression |
| Description | Facultatively anaerobic bacteria are able to adapt to many different growth conditions. Their capability to change their metabolism optimally is often ensured by FNR-like proteins. The FNR protein of Escherichia coli functions as the main regulator during the aerobic-to-anaerobic switch. Low oxygen tensions activate this protein which is expressed constitutively and is inactive under aerobic conditions. The active form is dimeric and contains a [4Fe-4S]2+ cluster. The direct dissociation of the cluster to the [2Fe-2S]2+ cluster by the effect of oxygen leads to destabilization of the FNR dimer and to loss of its activity. The active FNR induces the expression of many anaerobic genes; the set comprises over 100 of controlled genes. Many other bacteria contain one or more FNR analogues. For some bacteria, e.g. Paracoccus denitrificans, another mechanism of FNR-analogue inactivation was proposed that is based on redox effects of unknown intracellular components or of some parts of respiratory chain. |
| Related projects: |