Immunohistochemical differences in the ECM content alongside afferent and motor axons in relation to the position of the dorsal root ganglion

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Authors	SVÍŽENSKÁ Ivana KLUSÁKOVÁ Ilona GHALIB Nabil Ahmed DUBOVÝ Petr
Year of publication	2001
Type	Article in Periodical
Magazine / Source	The Histochemical Journal
MU Faculty or unit	Faculty of Medicine
Citation
Field	Neurology, neurosurgery, neurosciences
Description	The extracellular matrix (ECM) provides signalling cues that regulate cell behaviour during peripheral nerve formation and homeostasis. Composition of the ECM is the major determinant of the microenvironmental condition that controls the nerve regeneration. To reveal different microenvironmental conditions for motor and afferent axons we have analysed immunohistochemically some ECM components and adhesion molecules (laminin-2, -3, fibronectin, thrombospondin, tenascin, chondroitin sulphate, and HNK-1) in the spinal roots and branches of the spinal nerve. The results of quantitative immunofluorescence analysis suggest some differences in the content of ECM along the afferent and motor axons that could be involved in the origin of different conditions for the axon regrowth after injury of the dorsal and ventral roots as well as the spinal nerves.
Related projects:	Cellular and extracellular environment for the axon regenaration following injury of the spinal roots and peripheral nerves Plasticity of Regulatory Mechanisms of the Central Nervous Systems