Topography of genetic loci in tissue samples: towards new diagnostic tool using interphase FISH and high-resolution image analysis techniques

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Authors	KOUTNÁ Irena KOZUBEK Stanislav ŽALOUDÍK Jan KOZUBEK Michal LUKÁŠOVÁ Emilie MATULA Pavel BÁRTOVÁ Eva SKALNÍKOVÁ Magdalena CAFOURKOVÁ Alena JIRSOVÁ Pavla
Year of publication	2000
Type	Article in Periodical
Magazine / Source	Analytical Cellular Pathology
MU Faculty or unit	Faculty of Informatics
Citation
Web	abstract
Field	Genetics and molecular biology
Keywords	FISH; high-resolution image analysis
Description	Using single and dual colour fluorescence in situ hybridisation (FISH) combined with image analysis techniques the topographic characteristics of genes and centromeres in nuclei of human colon tissue cells were investigated.
Related projects:	How the study spatial order of specific genetic loci in nuclei of healthy and malignant tissues can contribute to the diagnostics and treatment of solid tumors. Image analysis in the study of mechanisms of induction, in diagnosis and for prevention of deleterious human diseases The use interphase FISH for the determination of individuals with elevated risk of the induction of hemoblastoses Application of computer image analysis in optical microscopy