Telomerase activity and expression in the course of treatment of acute childhood leukemias

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Authors

MALÁSKA Jan FAJKUS Jiří BAJER Milan HRSTKOVÁ Hana BAJEROVÁ Kateřina MICHÁLEK Jaroslav FAJKUSOVÁ Lenka VYZULA Rostislav KREJČÍ Kateřina SKLENIČKOVÁ Marie

Year of publication 2000
Type Article in Proceedings
Conference Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Telomerase activity
Description Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.
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