Využití fast eigenvector centrality ke sledování dynamiky fMRI dat v prodromálním stádiu demence s Lewyho tělísky
| Title in English | Using fast eigenvector centrality to monitor the dynamics of fMRI data in the prodromal stage of dementia with Lewy bodies |
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| Year of publication | 2023 |
| Type | Conference abstract |
| MU Faculty or unit | |
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| Description | Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer's disease. Mild Cognitive Impairment (MCI) The symptomatic period before the onset of dementia is called Mild Cognitive Impairment (MCI). DLB is caused by the accumulation of the protein alpha-synuclein (=Lewy bodies) between neurons in the brain. From the point of view of neuropsychology, dementia manifests itself as a disturbance of cognition manifested mainly by attention disorders, visual hallucinations, REM sleep disorders (RBD), and parkinsonism. Diagnosis can be made using biomarkers - a decrease in the uptake of the dopamine transporter (DaT) in the basal ganglia (SPECT/PET), polysomnography - diagnosis of RBD or brain atrophy imaging - a structural MRI analysis of brain functions and functional fMRI in resting state. This thesis uses fast eigenvector centrality to monitor the dynamics of fMRI data in the prodromal stage of dementia with Lewy bodies. |
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