Alpha mangostin inhibits proliferation, migration, and invasion of human breast cancer cells via STAT3 inhibition

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Authors

NALLA Lakshmi Vineela DHARAVATH Anil BEHERA Santosh Kumar KHAIRNAR Amit Suresh

Year of publication 2023
Type Article in Periodical
Magazine / Source ADVANCES IN CANCER BIOLOGY-METASTASIS
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S2667394023000035?via%3Dihub
Doi http://dx.doi.org/10.1016/j.adcanc.2023.100089
Keywords STAT3; PKM2; alpha-M; Breast cancer; Migration; And hnRNP-A1
Attached files
Description Signal Transducer and Activator of Transcription 3 (STAT3) is an identified critical protein associated with the progression of cancer. Alpha mangostin (alpha-M), a powerful dietary xanthone found to have anti-cancer properties against various cancers. However, the precise mechanism of its anti-cancer activity is not fully understood. Therefore, the current work hypothesized that targeting STAT3 with alpha-M inhibits the migration, invasion, and proliferation of breast cancer cells. Firstly, we evaluated the binding affinity of alpha-M/STAT3 complex using molecular dynamic simulations (MDS) and further we determined the likely underlying mechanism of STAT3 through in-vitro experiments. alpha-M treatment affected the levels of STAT3 phosphorylation, hnRNP-A1, PKM2, and EMT markers. alpha-M stimulation in breast cancer cells also resulted in suppressed migratory and invasive behaviour. More importantly, the treatment also affected the Ki67 and BrdU positive cells. In summary, we found the anti-migratory and anti-proliferative actions of alpha-M in breast cancer cells via STAT3 inhibition. Also, the study significantly adds a new nutraceutical for therapeutic intervention of invasive breast cancer.
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