Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats

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Authors	MUNZAR Patrik LAUFERT Michael D. KUTKAT Scott W. NOVÁKOVÁ Jana GOLDBERG Steven R.
Year of publication	1999
Type	Article in Periodical
Magazine / Source	The Journal of Pharmacology and Exper. Therapeutics
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://jpet.aspetjournals.org/content/291/1/239.long
Field	Pharmacology and pharmaceutical chemistry
Keywords	Rats; methamphetamine; serotonin agonists; serotonin antagonists; serotonin uptake inhibitors; discriminative behaviour
Description	The present data suggest that the 5-HT system plays a modulatory role in the discriminative stimulus effects of methamphetamine. These effects appear to be mediated through 5-HT release and blockade of reuptake and subsequent activation of 5-HT(2A/2C) receptors, with limited involvement of other 5-HT receptor subtypes.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems