Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats

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Authors

MUNZAR Patrik LAUFERT Michael D. KUTKAT Scott W. NOVÁKOVÁ Jana GOLDBERG Steven R.

Year of publication 1999
Type Article in Periodical
Magazine / Source The Journal of Pharmacology and Exper. Therapeutics
MU Faculty or unit

Faculty of Medicine

Citation
Web https://jpet.aspetjournals.org/content/291/1/239.long
Field Pharmacology and pharmaceutical chemistry
Keywords Rats; methamphetamine; serotonin agonists; serotonin antagonists; serotonin uptake inhibitors; discriminative behaviour
Description The present data suggest that the 5-HT system plays a modulatory role in the discriminative stimulus effects of methamphetamine. These effects appear to be mediated through 5-HT release and blockade of reuptake and subsequent activation of 5-HT(2A/2C) receptors, with limited involvement of other 5-HT receptor subtypes.
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