Effects of novel hydroxamic acids on cell cycle progression and cytodifferentiation

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Authors

MELICHAROVÁ Jana KAUEROVÁ Tereza ONUŠČÁKOVÁ Magdaléna BOBÁĽ Pavel KOLLÁR Peter

Year of publication 2022
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description At the Department of Chemical Drugs of the Pharmaceutical Faculty, Masaryk University, a new group of hydroxamic acids was designed and synthesized based on similarity to the structure of vorinostat. The aim of the project was to evaluate the effects of selected new hydroxamic acids on the processes of cell cycle progression and cytodifferentiation in the monocytic leukemia cell line and to compare these effects with the activity of a reference substance, vorinostat.
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