Differences in the induction of apoptosis after treatment with gamma-irradiation and C2-ceramide
| Authors | |
|---|---|
| Year of publication | 1999 |
| Type | Article in Proceedings |
| Conference | Fundamentals for the assesment of risks from environmental radiation |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Description | Cell death in organisms can be caused by two distinct mechanism: apoptosis and necrosis. These two processes were studied in human leukemic cell lines HL-60 and U-937 after exposure to g-radiation (6 Gy) and C2-ceramide (mM). Apoptosis was induced by C2-ceramide treatment in both cell lines, whereas after g-irradiation it was detected only in U-937 cells, whereas HL-60 cells died by necrosis. The different behaviour of U-937 and HL-60 cells is apparently caused by differences in expression of some protooncogenes in the two cell lines. Two different apoptotic pathways may exist: one, observed only after the exposure to C2-ceramide, is ceramide-induced apoptosis and the other, observed after g-radiation treatment, is p53-ependent |
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