Metabolická plasticita nádorových buněk

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Title in English Metabolic plasticity of cancer cells
Authors

RAUDENSKÁ Martina PELTANOVÁ Barbora HÖNIGOVÁ Kateřina NAVRÁTIL Jiří MASAŘÍK Michal

Year of publication 2022
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.linkos.cz/casopis-klinicka-onkologie/2022-06-15-3/metabolicka-plasticita-nadorovych-bunek/
Doi http://dx.doi.org/10.48095/ccko2022195
Keywords metabolism; cancer; glutaminolysis; Warburg effect; anaplerosis; Krebs cycle; oncogenesis; oncometabolite
Description A general characteristic of cancer metabolism is the skill to gain the essential nutrients from a relatively poor environment and use them eff ectively to maintain viability and create new bio mass. The changes in intracellular and extracellular metabolites that accompany metabolic reprogramming associated with tumor growth subsequently aff ect gene expression, cell diff erentiation, and tumor microenvironment. During carcinogenesis, cancer cells face huge selection pressures that force them to constantly optimize dominant metabolic pathways and undergo major metabolic reorganizations. In general, greater fl exibility of metabolic pathways increases the ability of tumor cells to satisfy their metabolic needs in a changing environment. Purpose: In this review, we discuss the metabolic properties of cancer cells and describe the tumor promoting eff ect of the transformed metabolism. We assume that changes in metabolism are signifi cant enough to facilitate tumorigenesis and may provide interesting targets for cancer therapy.
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