Study of Biological Activity of Novel Hydroxamic Acids Derived From Vorinostat as the Inhibitor of Histone Deacetylases

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Authors

KAUEROVÁ Tereza ONUŠČÁKOVÁ Magdaléna BOBÁĽ Pavel KOLLÁR Peter

Year of publication 2022
Type Conference abstract
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Histone deacetylase inhibitors (iHDACs), a class of epigenetic regulators, are substances with anticancer activity that is associated with inhibition of cell proliferation, induction of programmed cell death, inhibition of angiogenesis, and induction of the cytodifferentiation process in cancer cells. Hydroxamic acid derivatives are currently the most important group of iHDACs. Our study was focused on the evaluation of biological activity of new hydroxamic acids derivates as potential iHDACs designed and synthesised by the Department of Chemical Drugs in Faculty of Pharmacy at Masaryk University.
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