Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates

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Authors

ONUŠČÁKOVÁ Magdaléna PÍŽOVÁ Hana KAUEROVÁ Tereza KOLLÁR Peter BOBÁĽ Pavel

Year of publication 2021
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Histone deacetylases (HDACs) have been long linked with tumor progression, demonstrating their important role in neoplasia. Inhibitors of HDAC (HDACI), which form a complex with Zn2+ ions in the active site of enzymes, are novel anticancer agents that induce tumor cell death, differentiation, and/or cell cycle arrest. We have designed and synthesized a series of N-hydroxycinnamamide derivates based on common HDAC`s pharmacophore with diversely substituted anilides.
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