Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays andprotons in action
| Authors | |
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| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Applied Radiation and Isotopes |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.apradiso.2013.01.022 |
| Description | According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams. |
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