Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice

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Authors

HOFER M. HOFEROVA Z. DUŠEK Ladislav SOUČEK Karel GRUZDEV A.

Year of publication 2017
Type Article in Periodical
Magazine / Source Physiological research
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords Cyclooxygenase-2; COX-2 knock-out mice; Hematopoiesis; Ionizing radiation; Post-irradiation inflammation
Description We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.
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