Redox-Pair-Defined Electrochemical Measurements: Biamperometric Setup for Elimination of Interferent Effects and for Sensing of Unstable Redox Systems

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Authors

LACINA Karel VANÝSEK Petr BEDNÁŘ Petr TRNKOVÁ Libuše SKLÁDAL Petr

Year of publication 2016
Type Article in Periodical
Magazine / Source ChemElectroChem
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://onlinelibrary.wiley.com/doi/10.1002/celc.201600076/full
Doi http://dx.doi.org/10.1002/celc.201600076
Field Physical chemistry and theoretical chemistry
Keywords analytical methods; cyclic biamperometry; electrochemistry; redox chemistry; sensors
Description Routine, large-scale monitoring, such as point-of-care systems, requires inexpensive and simple analytical schemes. An electroanalytical concept of biamperometry for such sensing systems has been overlooked due to widespread potentiostat-controlled experiments. Herein, biamperometry is introduced as a powerful tool. In particular, its ability to eliminate electrochemical interference is highlighted for a case study on employing [Fe(CN)(6)](4-)/[Fe(CN)(6)](3-), aminoferrocene (Fe2+)/[Ru(NH3)(6)](3+), and ascorbic acid as two redox pairs and one interfering compound, respectively. A specific signal 15 times higher than that of an unspecific signal is observed, even under unfavorable conditions such as a 1:5 molar ratio of specific-to-interfering redox entities. This system is successfully used to determine glucose in blood plasma. A further promising usage of biamperometry is illustrated by the study of an unstable redox system: the oxygen-dependent oxidation of [Ru(NH3)(6)](2+) in an aqueous environment.
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