Studium selekce genomických abnormalit v průběhu chronické lymfocytární leukemie
| Title in English | Analysis of Genomic Abnormalities Selection during Chronic Lymphocytic Leukemia Course |
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| Authors | |
| Year of publication | 2016 |
| Type | Article in Proceedings |
| Conference | XL. brněnské onkologické dny |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | chronic lyphocytic leukemia; TP53 gene; chromothripsis |
| Attached files | |
| Description | Chronic lymphocylic Seukemia (CLL) represents a disease with highly variable clinical course, which is reflected a!so in significant CLL heterogeneity in terms of genomic defects identified. CLL-related therapy represents an important selection pressure contributing to further accumulation of genoroie abnormalities. According to our recent data, TP53 mutation occurs in a disease relapse in every sixth patient with the intact gene before treatment Identification of such patients prior therapy administration is clinically important as it may open a possibility to provide them alternative treatment options. Therefore, our aim was to assess genomic abnormalities preceding and accompanying TPS3 defect selection. Our findings point to the increased genomic instability of pre-treatment leukemie clones. Gain of additional genomic defects was noticed in the majority of relapse samples. Complex genomic rearrangements, called chromo-thripsis, were observed recurrently and were associated with a very adverse clinical course. |
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