Voltage Sensitive Dye di-4-ANNEPS Prolongs Impulse Conduction Through Ventricles, but not Through AV Node in Isolated Rabbit Heart
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Proceedings |
| Conference | Computing in Cardiology, 2015. |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | heart; di-4-ANNEPS; electrogram |
| Description | Voltage sensitive dye di-4-ANEPPS is widely used in studies of cardiac electrophysiology. Although reduction of cardiac impulse propagation and prolongation of RR interval in the presence of di-4-ANEPPS is known, the effect on impulse conduction through AV node has not been studied yet. In this study the quantification of di-4-ANEPPS impact on duration of impulse conduction through AV node and ventricles in isolated rabbit hearts was done. It can be concluded that voltage sensitive dye di-4-ANEPPS leads to prolongation of cardiac impulse conduction through the ventricles. Conduction through AV node is impaired only slightly. |
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