Analýza možností využití detekce gamaH2AX/53BP1 ohnisek a monitorování reparace dvouřetězcových zlomů DNA pro pre-terapeutické stanovení radiosensitivity nádorů hlavy a krku
| Title in English | Analysis of the use of detection gamaH2AX/53BP1 foci and monitoring of DNA double strand breaks repairs for pre-therapeutic evaluation of radiosensitivity of head and neck tumors |
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| Year of publication | 2015 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Surgical management head and neck cancers is often devastating, it is therefore preferred noninvasive chemo / radiotherapy. We dont have marker identifying patients responsive to ionizing radiation before start of treatment. Primarydecision for the optimal therapy is therefore extremely important. Our goal is to optimize detection gammaH2AX/53BP1 foci using immunofluorescence microscopy for pretreament determination of the sensitivity of tumors head and neck to ionizing radiation in vitro. |
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