THE EFFECT OF GLUCOSE VARIABILITY ON THE EXPRESSION OF GENES INVOLVED IN HYPERGLYCAEMIA-INDUCED TISSUE DAMAGE

Authors

PÁCAL Lukáš KURICOVÁ Katarína ŠOUPAL Jan PRÁZNÝ Martin KAŇKOVÁ Kateřina

Year of publication 2015
Type Conference abstract
Citation
Description Large prospective studies provided evidence of the relationship between long-term diabetes compensation expressed as HbA1c and the risk of diabetic cardiovascular complications. However, HbA1c and diabetes duration explain only small portion of the complications risk. Patients with the same HbA1c differ in amplitudes and duration of glycaemic excursions (so called glucose variability [GV]). Limited number of animal and in vitro studies showed that oscillating glucose may have more deleterious effect on cells than hyperglycaemia itself. Therefore, the aim of our study was to evaluate the effect of GV on the expression of genes whose products are involved in the development and protection against tissue damage in diabetes. Specifically, we measured gene expression of glyoxalase 1 (GLO1), and other enzymes with antioxidant activity – hemoxygenase (HMOX), superoxide dismutase 2 (SOD2) and enzyme with putative glyoxalase activity DJ1 in vitro.
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