A novel mutation leading to a premature stop codon in inlA of Listeria monocytogenes isolated from neonatal listeriosis

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Authors

GELBÍČOVÁ Tereza KOLÁČKOVÁ Ivana PANTŮČEK Roman KARPÍŠKOVÁ Renata

Year of publication 2015
Type Article in Periodical
Magazine / Source New Microbiologica
MU Faculty or unit

Faculty of Science

Citation
Web http://www.newmicrobiologica.org/PUB/allegati_pdf/2015/2/293.pdf
Field Microbiology, virology
Keywords truncated internalin A; sequencing; newborn; trans-placental barrier; listeria
Attached files
Description The study objective was to investigate whether the strain of L. monocytogenes serotype 1/2c isolated from neonatal listeriosis carries a premature stop codon (PMSC) mutation in the inlA gene. The strain was characterized by serotyping, macrorestriction analysis after digestion with the restriction enzyme AscI, and sequencing of the inlA gene. The tested strain of serotype 1/2c and pulsotype 1 possesses a new type of point mutation leading to a PMSC in the inlA gene and production of truncated internalin A. The case of early onset form of neonatal listeriosis caused by serotype 1/2c with a PMSC mutation in the inlA gene confirmed the transplacental transmission potential of this strain.
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