Isolated heart models: cardiovascular system studies and technological advances

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Authors

OLEJNÍČKOVÁ Veronika NOVÁKOVÁ Marie PROVAZNIK Ivo

Year of publication 2015
Type Article in Periodical
Magazine / Source Medical & Biological Engineering & Computing
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s11517-015-1270-2
Field Physiology
Keywords Isolated heart; Langendorff · Neely; Monophasic action potential; Electrogram
Description Isolated heart model is a relevant tool for cardiovascular system studies. It represents a highly reproducible model for studying broad spectrum of biochemical, physiological, morphological, and pharmaceutical parameters, including analysis of intrinsic heart mechanics, metabolism, and coronary vascular response. Results obtained in this model are under no influence of other organ systems, plasma concentration of hormones or ions and influence of autonomic nervous system. The review describes various isolated heart models, the modes of heart perfusion, and advantages and limitations of various experimental setups. It reports the improvements of perfusion setup according to Langendorff introduced by the authors.
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