Dihydropyrrolo[1,2-b]pyrazoles. Synthesis of New Derivatives and Their Biological Evaluation

Tenora,  Lukáš; Galeta,  Juraj; Kryštof,  Vladimír; Potáček,  Milan

Dihydropyrrolo[1,2-b]pyrazoles. Synthesis of New Derivatives and Their Biological Evaluation

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Authors	TENORA Lukáš GALETA Juraj KRYŠTOF Vladimír POTÁČEK Milan
Year of publication	2014
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	We present here our recent work aimed at the synthesis of some analogues with dihydropyrrolo[1,2-b]pyrazole (DPP) core bearing 2-pyridyl, 4-pyridyl and 4-quinolinyl moiety at position 2. Homoallenyl aldehyde is a key intermediate for the creation of DPP core. Various palladium catalyzed coupling reactions (Suzuki, Sonogashira, Heck, direct arylation and C-H activation) are shown in this work.
Related projects:	Allenyl synthon in synthesis of heterocyclic compounds