IMPROVING THE REPEATABILITY OF SAMPLING PROCEDURES FOR EXHALED BREATH CONDENSATE ANALYSIS

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Authors

GREGUŠ Michal KUBÁŇ Petr FORET František

Year of publication 2013
Type Article in Proceedings
Conference Chemické listy
MU Faculty or unit

Central European Institute of Technology

Citation
Web Chemické listy
Field Analytic chemistry
Keywords capillary electrophoresis; contactless conductivity detection; exhaled breath condensate; sampling device; standardization
Description A miniature sampler for exhaled breath condensate (EBC) collection was constructed and the repepatability of the collection procedure was studied. The samples were analyzed by CE-C4D home-made instrument. To improve the repeatability of the EBC collection, first the collection tubes, straws and vials require cleanup to remove unwanted interferents. Second, the breathing pattern should be kept uniform. We demonstrate that by adopting these measures, repeatability can be improved from 21.4– 186.5 % RSD (non-standardized sampling) to 3.6–80.3 % RSD (standardized sampling) and is comparable than with the commercial device (6.6–75.6 % RSD).
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