Nucleosomal TATA-switch: Competing orientations of TATA on the nucleosome

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Authors	HAPALA Jan TRIFONOV Eduard Nikolajevič
Year of publication	2013
Type	Article in Periodical
Magazine / Source	Gene
MU Faculty or unit	Central European Institute of Technology
Citation
Doi	http://dx.doi.org/10.1016/j.gene.2013.06.004
Field	Genetics and molecular biology
Keywords	TATA box; Eukaryotic promoter; Nucleosome mapping; Rotational positioning; Chromatin and transcription
Description	Transcription is known to be affected by the rotational setting of the transcription response elements within nucleosomes.Our results show that the nucleosome DNA sequence harboring the TATA box encodes alternative rotational positions for the same piece of DNA. This may serve for switching the gene activity on and off.
Related projects:	PlantGPPS - Rozvoj lidských zdrojů pro výzkum, vývoj a inovace v oblasti genomiky a proteomiky rostlinných systémů