Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies

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Authors

ODRÁŠKA Pavel DOLEZALOVA Lenka KUTA Jan ORAVEC Michal PILER Pavel SYNEK Stanislav BLÁHA Luděk

Year of publication 2014
Type Article in Periodical
Magazine / Source ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1080/19338244.2013.763757
Field Environment influence on health
Keywords antineoplastic agents; carcinogens; chemical exposure; cytotoxic drugs; exposure assessment; surface contamination
Description This study investigates the surface contamination levels of cyclophosphamide and platinum (a marker of platinum-containing drugs) in storage and preparation areas of hospital pharmacies and their relationship to working conditions surveyed by questionnaire. In total, 259 wipe samples were collected in 13 hospital pharmacies over 4 sampling campaigns. After sample extraction with acetate buffer, cyclophosphamide and platinum were determined using high-performance liquid chromatography-tandem mass spectroscopy (HPLC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS). Depending on the sampling spot and campaign, median concentrations ranged from <2 to 61 pg/cm(2) and from <0.2 to 6.9 pg/cm(2) for cyclophosphamide and platinum, respectively. Statistical evaluation of monitoring data revealed that the contamination level was significantly influenced by laboratory throughput (expressed as number of chemotherapies prepared per week), personnel expertise (ie, participation of pharmacists with academic education in drug admixture activities), and surface material.
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