Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review

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Authors

ŠERÝ Omar POVOVÁ Jana MÍŠEK Ivan PEŠÁK Lukáš JANOUT Vladimír

Year of publication 2013
Type Article in Periodical
Magazine / Source Folia Neuropathologica
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.5114/fn.2013.34190
Field Physiology
Keywords Alzheimer`s disease; amyloid precursor protein; tau protein; apolipoprotein E
Description More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.
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