Degradace proteinů ubikvitin-proteazomovou dráhou

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Title in English Degradation of proteins by ubiquitin-proteasome pathway
Authors

MATĚJÍKOVÁ Jana KUBICZKOVÁ Lenka SEDLAŘÍKOVÁ Lenka POTÁČOVÁ Anna HÁJEK Roman ŠEVČÍKOVÁ Sabina

Year of publication 2013
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords NF-kappa B; Proteasome; Proteasome inhibitors; Protein degradation; Ubiquitin
Description All intracellular and some extracellular proteins are continually degraded and replaced by synthesis of new proteins. Both these processes need to stay in equilibrium since their balance may lead to emergence of diseases. Cells contain many proteolytic systems that ensure highly specific and controlled degradation of proteins. One of these systems is the proteasome, a very complex molecular engine allowing degradation of proteins conjugated to ubiquitin. Since the first isolation of proteasome in 1968, many details about its function have been uncovered. In 2004, Nobel Prize for chemistry was awarded for these discoveries. In our review article, we aimed to summarize information about the mechanism of highly selective degradation of proteins by the ubiquitin-proteasome pathway. Individual parts of the paper summarize current knowledge about highly selective degradation of proteins by the ubiquitin-proteasome system, mechanisms of protein degradation regulation and biological effects of proteasome inhibitors.
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