Novel Electrochemical Biosensor for Simultaneous Detection of Adenine and Guanine Based on Cu2O Nanoparticles

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Authors

CHOMOUCKA Jana PRASEK Jan BUSINOVA Petra TRNKOVÁ Libuše DRBOHLAVOVÁ Jana PEKAREK Jan HRDY Radim HUBÁLEK Jaromír

Year of publication 2012
Type Article in Proceedings
Conference 26th European Conference on Solid-State Transducers, EUROSENSOR 2012
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1016/j.proeng.2012.09.244
Field Physical chemistry and theoretical chemistry
Keywords Thick film technology; electrochemistry; cyclic voltametry; copper(I) oxide; purines
Description In this paper Cu2O nanoparticles were prepared and used for the construction of novel electrochemical voltammetric biosensor for the simultaneous detection of adenine and guanine. Cu2O nanoparticles were synthesized via simple wet chemical route, where glucose was used as a reductant. The nanoparticles were characterized by SEM and XRD analysis, which showed the presence of spherical aggregations with diameter of 1000 nm. These nanoparticles were successfully used for fabrication of spray-coated and screen-printed working electrodes on alumina substrate for the electrochemical detection of purine bases. We observed that Cu(I) reacts with adenine to form insoluble complex that accumulates on the electrode surface and causes the decrease of current response. In the case of guanine, we did not observed any significant decrease of current response which is probably caused by adsorption of guanine on the electrode surface.
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