Origin and evolution of genes and genomes. Crucial role of triplet expansions

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Authors

TRIFONOV Eduard Nikolajevič FRENKEL Zakharia M

Year of publication 2012
Type Article in Periodical
Magazine / Source J. Biomol. Struct. Dynamics 12
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.tandfonline.com/doi/abs/10.1080/07391102.2012.677771
Doi http://dx.doi.org/10.1080/07391102.2012.677771
Field Genetics and molecular biology
Keywords triplet expansion; repeats; codon usage; gene evolution
Description A novel concept on mechanisms of evolution of genes and genomes is suggested: the sequences evolve largely by local events of triplet expansion and subsequent mutational changes in the repeats.Life which, presumably, started with replication of expanding triplets and their subsequent mutational changes, is continuing to emerge within the genes and genomes, in form of new events of triplet expansion.
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