Invazivní mykotické infekce u imunokompromitovaných nemocných se zaměřením na aspergilózu a její původce

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Title in English Invasive fungal infections in immunocompromised patients with focus on aspergillosis and its causative agents
Authors

PALOUŠOVÁ Dita LENGEROVÁ Martina VOLFOVÁ Pavlína BEJDÁK Petr KOCMANOVÁ Iva MAYER Jiří RÁČIL Zdeněk

Year of publication 2012
Type Article in Periodical
Magazine / Source Klinická mikrobiologie a infekční lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords fungal infection; aspergillosis; molecular genetics; immunodeficiency
Attached files
Description Invasive fungal diseases (IFD) are a life-threatening infectious complications in immunocompromised patients and are associated with high rate of morbidity and mortality. The most common invasive mycosis in patients who underwent an allogeneic hematopoietic stem cell transplantation is invasive aspergilosis (IA), most frequently caused by the clinically dominant species Aspergillus fumigatus and, rarely, also by Aspergillus flavus, Aspergillus terreus and Aspergillus niger. In recent years, other related Aspergillus species were also reported to cause IFD, phenotypically similar to A. fumigatus and moreover, frequently exhibiting resistance towards various antifungals. For example, it is Aspergillus lentulus, Aspergillus viridinutans, Neosartoya fischeri, etc. Classical microbiological methods such as direct microscopy or culture are usually used for the identification of Aspergillus species. The application of PCR-based molecular techniques and monitoring of secondary metabolites production enable detection and identification of species, which are not distinguishable solely by their morphology. PCR methods are also useful for molecular strain typing of aspergilli and can reveal the genetic diversity of isolates.
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