Exprese nestinu i v nádorových buňkách hematologických malignit - leukémií a lymfomů
| Title in English | Nestin expression in tumor cells of hematological malignancies. |
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| Authors | |
| Year of publication | 2012 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Protein nestin is considered a marker of immature (stem/progenitor) cells and its expression occurs during mammalian embryogenesis. Re-expression of nestin occurs in various pathologic conditions; one of them is a neoplastic transformation. Nestin has been detected in the whole range of solid tumors where its expression correlates with tumor malignancy and invasiveness. Therefore, nestin is thought to be negative prognostic marker. In addition, some nestin-positive populations of tumor cells have the same features as CSCs responsible for tumor relapse according to CSCs hypothesis. Our pilot data proved nestinin tumor cells of various leukemia and lymphoma cell lines, as well as in patients with CLL and other hematooncological diagnoses. Importance of nestin detection is seen in the opportunity of enlargement the group of prognostic markers of CLL and other hematooncologic disorders, therefore, in possibility of better stratification and treatment of oncologic patients. |
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