Project information
Biomolecular centre

Information

This project doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official project website can be found on muni.cz.

Project Identification

LC06030

Project Period

3/2006 - 12/2011

Investor / Pogramme / Project type

Ministry of Education, Youth and Sports of the CR

Basic Research Center

MU Faculty or unit

Central European Institute of Technology

prof. RNDr. Vladimír Sklenář, DrSc.

Keywords

Cancer drugs, biosensors, lectins, molecular modeling of biomolecules, biomolecular NMR

Cooperating Organization

Institute of Biophysics

Responsible person prof. RNDr. Jiří Šponer, DrSc.

Veterinary Research Institurte

Responsible person doc. RNDr. Ivan Rychlík, Ph.D.

The main goal of the project is to elevate the structural biology in the Czech Republic from studies of individual biomacromolecules to investigations of their complexes. This goal will be achieved by implementation of up-to-date methodology in selected scientific fields (NMR spectroscopy, computational modeling) and by focusing on problems, which are currently in the centre of interest of contemporary life sciences. Among others, key cell processes such as preservation of genome stability and DNA repair, ribosomal protein synthesis, or information transfer by recognition (lectins) will be studied. Selected research projects will lead eventually to bioanalytical (biosensors) and biomedical (vaccines, chemotherapeutics) outcomes with potential applications in research and development. To reach the outlined goals, active collaboration of participating institutions is inevitable. A number of projects will require also a broad international collaboration.

Results

The main goal of the project is to help to drive structural biology in the Czech Republic from studies on single biomacromolecules to studies on biomacromolecular complexes. To achieve the goal, we will implement recent advances in selected key methods in the field (NMR spectrometry, computer modeling) and also contribute to their development. The research will be oriented not only to the structure of biomacromolecules but will also include studies of structure/function relationship. It will touch suchimportant phenomena of the cell life as keeping genome stability, DNA repair, protein synthesis in the ribosome or information transfer via recognition (lectins). Selected parts of the research will be devoted to bioanalytical (biosensors) or biomedicinal(vaccines, chemotherapeutics) projects capable of providing results with potential applications at the practical level. By solving the above scientific tasks, the team will increase its international competitiveness. At the same time, the project will

Publications

Total number of publications: 284

2009

Effects of Restrained Sampling Space and Nonplanar Amino Groups on Free-Energy Predictions for RNA with Imino and Sheared Tandem GA Base Pairs Flanked by GC, CG, iGiC or iCIG Base Pairs

YILDIRIM Ilyas STERN Harry ŠPONER Jiří ŠPAČKOVÁ Naděžda TURNER Douglas

Article in Periodical

Journal of Chemical Theory and Computation, year: 2009, volume: 5, edition: 8
Electron Density Shift in Imidazolium Derivatives upon Complexation with Cucurbit[6]uril

KOLMAN Viktor MAREK Radek STŘELCOVÁ Zora KULHÁNEK Petr NEČAS Marek ŠVEC Jan ŠINDELÁŘ Vladimír

Article in Periodical

Chemistry - A European Journal, year: 2009, volume: 15, edition: 28, DOI
Experimental and quantum-chemical studies of 1H, 13C and 15N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with picolines

PAZDERSKI Leszek TOUŠEK Jaromír SITKOWSKI Jerzy MALIŇÁKOVÁ Kateřina KOZERSKI Lech SZLYK Edward

Article in Periodical

Magnetic Resonance in Chemistry, year: 2009, volume: 47, edition: 3
Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption.

SIERRA Colavito MARGARET Macris-Kiss CHANGHYUN Seong OLIVE Gleeson ERIC C. Greene HANNAH L. Klein LUMIR Krejci PATRICK Sung

Article in Periodical

Nucleic Acids Research, year: 2009, volume: 20, edition: 37
Charge Localization on Imidazolium Ring upon Complexation with Cucurbit[6]uril

KOLMAN Viktor MAREK Radek STŘELCOVÁ Zora KULHÁNEK Petr NEČAS Marek ŠVEC Jan ŠINDELÁŘ Vladimír

Conference abstract

Year: 2009, type: Conference abstract
Implementation and Testing of Multiple Walkers Approach Based Free Energy Calculations in the Grid Environment

STŘELCOVÁ Zora KULHÁNEK Petr KMUNÍČEK Jan KOČA Jaroslav MATYSKA Luděk

Article in Proceedings

GCCP Proceedings, year: 2009
Implementation of Parallel Analyzes of Molecular Dynamics Simulation Trajectories

ŠTĚPÁN Jakub KULHÁNEK Petr KOČA Jaroslav MISHRA Navnit Kumar

Conference abstract

Year: 2009, type: Conference abstract
Importance of oligomerisation on Pseudomonas aeruginosa Lectin-II binding affinity. In silico and in vitro mutagenesis.

WIMMEROVÁ Michaela MISHRA Navnit Kumar POKORNÁ Martina KOČA Jaroslav

Article in Periodical

Journal of Molecular Modeling, year: 2009, volume: 15, edition: 6
Investigating effect of ionic strength on conformational behavior of beta amyloids

KŘÍŽ Zdeněk KRIŠTOFÍKOVÁ Zdena KOČA Jaroslav

Conference abstract

Year: 2009, type: Conference abstract
Investigation of mutation-induced binding preference changes of CV-IIL lectin

BRŮNOVÁ Lenka ADAM Jan WIMMEROVÁ Michaela

Conference abstract

Year: 2009, type: Conference abstract